It's not her first talk show, but it is a first of its kind. Ideas, people and places that fascinate her, all in her unique style.
Top Billed Cast
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Chelsea Handler
Herself - Host (120 episodes)
Jason Biggs
Self (3 episodes)
Jenny Mollen
Self (3 episodes)
Wanda Sykes
Self (2 episodes)
Barbara Boxer
Self (2 episodes)
Kate Hudson
Self (2 episodes)
Eric André
Self (2 episodes)
Neil deGrasse Tyson
Self (2 episodes)
Sarah Silverman
Self (2 episodes)
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