Cast 75
John Mulaney
John (13 episodes)
Elliott Gould
Oscar (13 episodes)
Zack Pearlman
Andre (13 episodes)
Nasim Pedrad
Jane (13 episodes)
Seaton Smith
Motif (13 episodes)
Martin Short
Lou (13 episodes)
Julie Klausner
Donna (3 episodes)
Fortune Feimster
Mary Jo (3 episodes)
Carole Goldman
Mrs. Tuchman (2 episodes)
Tessa Goss
News Anchor (2 episodes)
Karey Dornetto
Brenda (1 episode)Mom (voice) (1 episode)
Kayla Maisonet
Teen Girl (1 episode)
Dean Cain
Dean Cain (1 episode)
Keisuke Hoashi
Dr. Cho (1 episode)
Leon Simmons
Ernie (1 episode)
David Theune
Stage Manager (1 episode)
Maria Thayer
Amanda (1 episode)
Jack Axelrod
Elderly Veteran (1 episode)
Ayumi Iizuka
Mother (1 episode)
Lyle Kanouse
Teamster (1 episode)
Tess Paras
Female Contestant (1 episode)
Laura Bailey
Narrator (voice) (1 episode)
Dan Levy
Dad (voice) (1 episode)
Lordan Napoli
Stacy (voice) (1 episode)
Bruce M. Stockert
Man at Bris (1 episode)
Dan Mintz
Mintz (1 episode)
Bunny Levine
Old Woman (1 episode)
Penny Marshall
Tutti (1 episode)
Lorraine Bracco
Vaughn (1 episode)
Megan Heyn
Kristen (1 episode)
Duane R. Shepard Sr.
Percy (1 episode)
Nora Dunn
Patty Mulaney (1 episode)
Pete Holmes
Father Trey (1 episode)
James Handy
Father Ed (1 episode)
Art Napiontek
Ripped Andre (1 episode)
Greta Sesheta
Cantor (1 episode)
Ben Lawson
Greg (1 episode)
Jerry Minor
Murphy (1 episode)
Robert Baker
Chad (1 episode)
Rocky McMurray
Recruiter (1 episode)
Nico Santos
Contestant (1 episode)
Adria Tennor
Flight Attendant (1 episode)
Corey Martin Craig
Young Man (1 episode)
Brennan Feonix
Audience Member (1 episode)
Kareem J. Grimes
Audience Member (1 episode)
Scott Broderick
Audience Member (1 episode)
Christopher Kager
Contestant (1 episode)
Jamie Denbo
Sharisse (1 episode)
Joy Osmanski
Alexa (1 episode)
Eddie Pepitone
Arnie (1 episode)
Brooke Lyons
Cassidy (1 episode)
Sonya Eddy
Gerta (1 episode)
Irene Roseen
Mrs. Regenbogen (1 episode)
Nick Kroll
Jesse Tyler Munoz (1 episode)
Ron Funches
Rodney (1 episode)
Tanner Flood
Young Mulaney (1 episode)
Edward Enriquez-Cohen
Stage Hand O.C. (1 episode)
Leonard Jackson
Crew Member (1 episode)
Danielle Kaplowitz
Woman (1 episode)
Jen Reiter
Casting Director O.C. (1 episode)
Liz Porter
Dancer (1 episode)
Molly Shannon
Markie (1 episode)
Bechir Sylvain
Bobby (1 episode)
Ron G.
Darren (1 episode)
J.M. Longoria
Photographer (1 episode)
Thomas Crawford
French Waiter (1 episode)
Kamala Jones
Hot Blonde (1 episode)
Leena Huff
Girl (1 episode)
Danielle Moné Truitt
Girl (1 episode)
Kristi Clainos
Girl (1 episode)
Bailee Madison
Ruby (1 episode)
Frankie Shaw
Julia (1 episode)
Barak Hardley
Paul (1 episode)
Victoria Grace
Teen (1 episode)
Natasha Leggero
Rodeo (1 episode)